新型阿霉素肿瘤靶向给药系统的合成及其性质研究
【摘要】：恶性肿瘤严重危害人类健康与生存，是引起死亡的主要原因之一。阿霉素作为一种广谱抗肿瘤药物，临床上主要用于治疗乳腺癌、儿童实体瘤、软组织瘤、恶性淋巴癌等多种恶性肿瘤。但其心脏毒性、骨髓抑制及消化道不良反应限制了临床应用。本文将对阿霉素剂型研究进展以及阿霉素前药进行初步研究。
【关键词】：阿霉素、肿瘤、前药、靶向
Study on properties and synthesis of new-type doxorubicin tumor- targeting drug delivery system
Pharmaceutics 1041917 TianFengChun
[ Abstract ]：Malignant tumor is a severe threatens to human healthy and survival, which is a main cause of disease leading death. Doxorubicin is a broad-spectrum
antitumor drug, which is often an essential component of treatment of breast cancer, children solid tumor, soft tissue sarcomas, and aggressive lymphomas. However, its cardiac toxicity, bone marrow suppression and gastrointestinal side effects limit its clinical application. This article studies on research progress of doxorubicin dosage form and doxorubicin prodrug.
[ Key words ]：Doxorubicin, tumor, prodrug，target
